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Besides initiating infection 7 For instance, Pfizer’s biodistribution study, … ‘Terrifying’ new research finds vaccine spike protein unexpectedly in bloodstream. New study: Covid's spike protein plays a key role in ... Spike Protein The Salk Institute article refers to this science paper published in Circulation Research: SARS-CoV-2 Spike Protein Impairs Endothelial Function via Downregulation of ACE 2. to pay for it! Mutation Y453F in the spike protein of SARS-CoV-2 enhances interaction with the mink ACE2 receptor for host adaption PLoS Pathog . SARS-CoV-2 Spike Protein Impairs Endothelial Function via Downregulation of ACE 2 Yuyang Lei, et al. SARS-CoV-2 infection relies on the binding of Spike glycoprotein (S protein) to angiotensin converting enzyme 2 (ACE2) in the host cells. Spike SGT - December 3, 2021. The paper, published on April 30, 2021, in Circulation Research, also shows conclusively that COVID-19 is a vascular disease, demonstrating exactly how the SARS-CoV-2 virus damages and attacks the vascular system on a cellular level. Thickened alveolar septa (red arrowhead) and mononuclear cell (red arrow). Ultrasensitive blood test detects viral protein, confirms ... Novel coronavirus' spike protein plays additional key role ... It has been shown previously in the murine model, that the expression of angiotensin-converting enzyme 2 (ACE2) on the cell surface is downregulated in response to the infection by SARS-CoV virus or recombinant spike protein (S protein) alone. SARS-CoV-2 differs from the original SARS-CoV by 380 amino acid substitutions, which translates to differences in five of the six vital amino acids in the receptor-binding domain between the viral spike (S) protein with surface expressed human ACE2. You will find the scientific literature referencing the dangers of “SARS-COV2” are interchanging that term with “spike protein” PubMed is full of papers explaining how the inflammatory “spike protein” attaches to an enzyme in the cardiovascular (and other) systems (the angiotensin converting enzyme 2). ... researchers reported on Friday in Circulation Research. Why Submit to Circulation Research; Announcements. The capacity of SARS-CoV-2 to infect vascular cells is still debated. 7 For instance, Pfizer’s biodistribution study, … J. Virol. https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.121.318902 The spike protein of SARS-CoV-2 allows the virus to bind to and infect cells, making it an ideal target for vaccine development. Illustration of SARS-CoV-2 spike protein binding with ACE2 Receptor. Take a look at this clip from an explosive paper that shows how the spike protein enters the nucleus of our cells causing incalculable damage to the immune system. “Spike protein is a deadly protein,” Dr. Peter McCullough, an internist, cardiologist and trained epidemiologist, says in a video. The Salk Institute article refers to this science paper published in Circulation Research: SARS-CoV-2 Spike Protein Impairs Endothelial Function via Downregulation of ACE 2. COVID-19 spike protein damages blood vessels. Research in context Evidence before this study: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) uses primarily the capsid spike (S) protein to engage with its receptors and infect host cells. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes a broad range of clinical responses including prominent microvascular damage. Scale bar=20 μm. Sui, J. et al. From the medical journal Circulation Research: The spike protein is what’s causing the damage. LA JOLLA-- (April 30, 2021) Scientists have known for a while that SARS-CoV-2's distinctive "spike" proteins help the virus infect its host by latching on to healthy cells. 7. ... published on April 30, 2021, in Circulation Research, also shows conclusively that COVID-19 is a vascular disease, demonstrating exactly how the SARS-CoV-2 virus damages and attacks the vascular system on a cellular level. Previous investigators demonstrated that the SARs-CoV-2 Spike (S) protein decreases tissue ACE2 by protein internalization or shedding. Because the RBD is the part of the spike that attaches directly to human cells and enables the virus to infect them, it was rightly assumed to be a primary target of the immune system. Abstract. OBEY THE FAUCI: Cardiology researchers are BURYING their own research showing spike protein mRNA damage due to fear of losing grant money controlled by Fauci. Circulation Research . COVID-19 spike protein damages blood vessels. We tested this … ... SARS-CoV-2 Spike Protein Impairs Endothelial Function via Downregulation of ACE 2. SARS-CoV-2 Spike Protein Elicits Cell Signaling in Human Cells. Recombinant human ACE2 protein and anti-Spike monoclonal antibody could inhibit SARS-CoV-2 Spike protein-induced platelet activation. AHA Journal COVID-19 Resources and Articles. 15 Salk Institute, April 30, 2021. In the discussion the authors address the potential effects of vaccine-generated antibodies against the spike protein. Mike ... there’s a research paper that appeared recently in the prestigious Circulation magazine that draws the same conclusion. SARS-CoV-2's distinctive "spike" proteins have been known to infect its host by latching on to healthy cells, but scientists have, in a new study, showed that they also play a key role in the disease. Both membrane bound and soluble ACE2 are integral parts of the Renin Angiotensin Aldosterone System (RAAS) that exists to keep the body's blood pressure in check. Research cited below has documented that the viral spike protein is able to initiate a cascade of events that triggers damage to distant organs in COVID-19 patients. The spike protein (S protein) is a large type I transmembrane protein ranging from 1,160 amino acids for avian infectious bronchitis virus (IBV) and up to 1,400 amino acids for feline coronavirus (FCoV) (Figure 1). It is the Spike protein, injected directly into a person's body, along with an adjuvant to make the immune reaction that much more vigorous. 7. Coronavirus disease 2019 (COVID-19) includes the cardiovascular complications in addition to respiratory disease. On the other hand, the adaptation of SARS-CoV-2 to different hosts causes mutations in different parts of the spike protein. Exosomes with spike protein and Abs decreased in parallel after four months. Spike protein was detected in 3-of-13 participants an average of 15 days after the first injection. The most likely culprit that has been identified is the COVID-19 spike protein released from the outer shell of the virus into circulation. While the three COVID-19 vaccines authorized for emergency use in the U.S. induce … According to the Doctor, who cites a brand new, peer-reviewed research study out of Japan "They made a mistake - they thought the spike protein was a great target antigen, only… Real-world evidence shows that the COVID-19 RNA vaccines are highly effective at preventing illness and death. SARS-CoV-2 spike protein triggers cell signaling pathways in lung vascular cells. Close this menu. Male sex is a risk factor for SARS-CoV-2 severity. by Ethan Huff, Natural News: There is a massive coverup taking place with regard to the substantial spike in heart disease that is now occurring ever since Wuhan coronavirus (Covid-19) “vaccines” were introduced under Operation Warp Speed. This effect was also true against the spike protein mutations from the predominant variants in circulation, including the United Kingdom (B.1.1.7), South African (B.1.351) and Brazilian (P.1) variant. is from nanoparticles. ... researchers reported on Friday in Circulation Research. The Salk Institute article refers to this science paper published in Circulation Research: SARS-CoV-2 Spike Protein Impairs Endothelial Function via Downregulation of ACE 2. SARS-CoV-2 and its Spike protein directly stimulated platelets to facilitate the release of coagulation factors, the secretion of inflammatory factors, and the formation of leukocyte–platelet aggregates. From kidney failure to strokes, COVID-19 can cause a wide range of complications from head to toe. Circulation Research, also shows conclusively that COVID-19 is a vascular disease, demonstrating ... animal model—proving that the spike protein alone was enough to cause disease. Effects of human anti–spike protein receptor binding domain antibodies on severe acute respiratory syndrome coronavirus neutralization escape and fitness. It was found that the treatment of cultured primary human pulmonary artery smooth muscle cells (SMCs) or human pulmonary artery endothelial cells with the recombinant SARS-CoV-2 spike protein S1 subunit is sufficient to promote cell signaling without the rest of the viral components []. 6 It may cause inflammation and clotting in any tissue in which it accumulates. Experts revealed that transmission is happening… SARS-CoV-2 infection impairs endothelial function and induces vascular inflammation, leading to endotheliitis. Now, a major new study shows that the virus spike proteins also play a key role in the disease itself. After the second vaccine dose, no S1 or Spike was detectable. These include fibrin(ogen), Spike proteins can circulate in your body after infection or injection, causing damage to cells, tissues and organs. And when you say: “Nothing can be deduced from just 10 autopsies”, you are very much mistaken. 2021 Apr 30;128 (9):1323-1326. doi: 10.1161/CIRCRESAHA.121.318902. by Planet Today-Thursday, ... (U.K.) to discuss the findings of … “In short, the conclusion is, we made a big mistake,” he said. You can detect a pattern of vaccine-generated disease that is produced by the injection of a toxic substance (spike protein) that causes bleeding, clotting and autoimmunity even in the people who survive. The spike protein binds to the ACE2 receptor on cells, downregulates their function, and causes damage to the endothelium cells that line lung tissue and blood vessels. Circ Res. 2021 Nov 8;17(11):e1010053. In the case of natural infection, circulation of the S protein in a soluble form is unlikely. Research "Game-changer": Spike Protein Increases Heart Attacks and Destroys Immune System. doi: 10.1371/journal.ppat.1010053. A, Representative H&E histopathology of lung specimens from 8- to 12 wk-old male Syrian hamsters 5-day post administration of pseudovirus overexpressing Spike protein (Pseu-Spike) or mock virus in control group (n=3 mice per group, 1×10 8 PFU). New York, May 2 : SARS-CoV-2’s distinctive “spike” proteins have been known to infect its host by latching on to healthy cells, but scientists have, in a new study, showed that they also play a key role in the disease. The findings of the new study were published in the scientific journal Circulation Research. Spike Protein Damages Endothelial Cells and Hurts Heart. The protein is linked to blood clots, heart and brain damage, and potential risks to nursing babies and fertility by Celeste McGovern May 31, 2021 (LifeSiteNews) — New research shows that the coronavirus spike protein from COVID-19 vaccination unexpectedly enters the … It has been shown previously in the murine model, that the expression of angiotensin-converting enzyme 2 (ACE2) on the cell surface is downregulated in response to the infection by SARS-CoV virus or recombinant spike protein (S protein) alone. The mRNA or adenovirus from the vaccines does not distribute extensively given that it’s an intramuscular injection, and the spike protein is highly unlikely to attain concentrations in the circulation anywhere near the high levels produced by the model used in … ... researchers reported on Friday in Circulation Research. And here’s the study, from Georgetown and the Ukraine, “SARS-CoV-2 Spike Protein Elicits Cell Signaling in Human Host Cells: Implications for Possible Consequences of COVID-19 Vaccines“. Research ‘Game-changer’: Spike Protein Increases Heart Attacks and Destroys Immune System December 19, 2021 Winter Watch Around the Web , US News 0 PHOTO: North County Daily Star They showed that the spike protein damaged the cells by binding ACE2. The Salk Institute article refers to this science paper published in Circulation Research: SARS-CoV-2 Spike Protein Impairs Endothelial Function via Downregulation of ACE 2. Dr. J. Patrick Whelan is a pediatric rheumatologist who warned the FDA of the microvascular injury the vaccine may cause to the kidneys, brain, liver and heart before it was released to the public. ... 2021, in Circulation Research, also shows conclusively that COVID-19 is a vascular disease, demonstrating exactly how the SARS-CoV-2 virus damages and attacks the vascular system on a cellular level. Also read article from the International nanotech Institute on adverse effects n hazards by Dr wim yong. Vascular endo- thelium can be infected by SARS-CoV-2,1which triggers mitochondrial reactive oxygen species production and glycolytic shift.2Paradoxically, ACE2 is protective in the cardiovascular system, and SARS-CoV-1 S protein pro- “Spike protein is a deadly protein,” Dr. Peter McCullough, a trained internist, cardiologist and epidemiologist, says in a video. Experiments showed that binding of spike protein subunit 1 increased barrier permeability in the engineered vessel-like constructs. Claim: The spike protein in COVID-19 vaccines is a "toxin" that accumulates "in a number of tissues" and could lead to cardiovascular and neurological damage. Scale bar=20 μm. SARS-CoV-2 infection relies on the binding of Spike glycoprotein (S protein) to angiotensin converting enzyme 2 (ACE2) in the host cells. B cells against the SARS-CoV-2 spike protein remain detectable in the circulation of most recovered COVID-19 patients and are stable or decay slowly at this time point. Vaccine skeptics have seized on the study to cast doubt on the safety of vaccines. NATIONNEWSDESK 31 MAY 2021 Audio from a radio show has emerged wherein Dr. Byram Bridle reveals the scientists behind the COVID-19 "Vaccine" made a terrible mistake. Referring to the new research, Dr Bridle said there was now “clear-cut evidence” that the vaccine spike protein spreads into the bloodstream, where it has the potential to damage organs. Research cited below has documented that the viral spike protein is able to initiate a cascade of events that triggers damage to distant organs in COVID-19 patients. 6 It may cause inflammation and clotting in any tissue in which it accumulates. 2021 ;128 :1323-1326 April 30, 2021 Please use one of the following formats to cite this article in your essay, paper or report: APA. Dr. Aseem Malhotra appeared on GB News (U.K.) to discuss the findings of a new abstract published in the journal … Bridle also cited another study that - he claimed - found: “A spike protein in circulation in the blood of 11 of those 13 healthcare workers that had received the vaccine.” Spike proteins can circulate in your body after infection or injection, causing damage to cells, tissues and organs. From the medical journal Circulation Research: The spike protein is what’s causing the damage. Depending on the cell type that binds the spike protein, any of a number of autoimmune medical conditions can result. Real-world evidence shows that the COVID-19 RNA vaccines are highly effective at preventing illness and death. Rather, it’s more like a “news and views” or opinion piece, a review article if you’re feeling particularly generous. Tissue samples Circulation Research November 24, 2021 Alternative Splicing Mediated by RNA-Binding Protein RBM24 Facilitates Cardiac Myofibrillogenesis in a Differentiation Stage-Specific Manner Serena Huei-An Lu, Kang-Zheng Lee, Paul Wei-Che Hsu, Liang-Yu Su, Yu-Chen Yeh, Chien-Yuan Pan and Su-Yi Tsai Circulation Research November 23, 2021 OBEY THE FAUCI: Cardiology researchers are BURYING their own research showing spike protein mRNA damage due to fear of losing grant money controlled by Fauci. Please use one of the following formats to cite this article in your essay, paper or report: APA. Additionally, the SARS-CoV-2 Spike (S) protein may act as a ligand to induce non-infective cellular stress. Fauci interview concerning universal flu vac. The most likely culprit that has been identified is the COVID-19 spike protein released from the outer shell of the virus into circulation. Exosomes with spike protein, Abs to SARS-CoV-2 spike, and T cells secreting IFN-γ and TNF-α increased following the booster dose. mRNA vaccines directed at the SARS-CoV-2 spike protein resulted in development of Abs and protective immunity. Scientists have known for a while that SARS-CoV-2's distinctive "spike" proteins help the virus infect its host by latching on to healthy cells. Previous research focused on one group of antibodies that target the most obvious part of the coronavirus's spike protein, called the receptor-binding domain (RBD). SARS-CoV-2 Spike Protein Elicits Cell Signaling in Human Cells. 3. Fig. Furthermore, it appears that some of the circulating spike proteins simply bind the ACE2 receptors without entering the cell, inducing an autoimmune response to the entire cell-spike protein entity. Research ‘Game-changer’: Spike Protein Increases Heart Attacks and Destroys Immune System December 19, 2021 Winter Watch Around the Web , US News 0 PHOTO: North County Daily Star Thomas, Liji. 0. https://www.ahajournals.org/doi/abs/10.1161/CIRCRESAHA.121.318902 Using mrna, spike protein n the H protein n how to get the Gov. Circulation Research; 115(4): 450-459, 2014 (Accompanying editorial: Touyz, RM Circ Res 2014, 115:412-414). Yes. There is a massive coverup taking place with regard to the substantial spike in heart disease that is now occurring ever since Wuhan coronavirus (Covid-19) “vaccines” were introduced under Operation Warp Speed.. Dr. Aseem Malhotra appeared on GB News (U.K.) to discuss the findings of a new abstract published in the journal Circulation, which basically … Co-receptors and host cell proteases may also be involved. It turns out that this “study” isn’t even a study at all. Thomas, Liji. Key mutations in the P.1 spike protein are similar to those in the B.1.351 lineage, although they arose independently: — N501Y, which helps the virus latch on more tightly to human cells. But before antibodies against spike protein are generated, the body must produce the spike proteins in the first place. See article from the Nov. 2017 Smithsonian. This can bring about the destruction of any cell that manufactures the SARS-CoV-2 spike protein, particularly in the circulation. The dandelion blocked the protein-to-protein interactions between the S1 sub unit of the spike protein and the human ACE2 cell surface receptor. The binding of the spike protein to an ACE2 binding site, but just remaining bound to that site and not initiating enzymatic degradation of the cell wall, with or without an attached virion; The degree to which circulating spike protein is present in the blood and actively disseminating throughout the body ... 13, 14 Circulation Research, 2021; 128:1326. Knowledge of the underlying biology and physiology of ACE2 (angiotensin-converting enzyme 2) has accumulated over the last 20 years since its discovery and has provided a major stimulus to further our understanding of the renin-angiotensin system (RAS). SARS-CoV-2 Spike Protein Impairs Endothelial Function via Downregulation of ACE 2 (Circulation Research) The novel coronavirus’ spike protein plays additional key role in illness - Salk Institute for Biological Studies (Salk Institute) SARS-CoV-2 spike protein impairment of endothelial function does not impact vaccine safety (Salk Institute) (2021, December 21). Angiotensin-converting enzyme 2 (ACE2) is the well- If that happens to the endothelia, that is, the cell layer that lines the inner surfaces of our blood vessels, then those vessels may begin to leak and clots will form. COVID-19 spike protein damages blood vessels ... researchers reported on Friday in Circulation Research. NATIONNEWSDESK 31 MAY 2021 Audio from a radio show has emerged wherein Dr. Byram Bridle reveals the scientists behind the COVID-19 "Vaccine" made a terrible mistake. New research: Besides initiating infection, coronavirus spike protein has key role in illness The paper also finds that Covid-19 is a vascular disease, demonstrating exactly how the SARS-CoV-2 virus damages and attacks the vascular system (comprising the blood vessels) on a cellular level. (Natural News) There is a massive coverup taking place with regard to the substantial spike in heart disease that is now occurring ever since Wuhan coronavirus (Covid-19) “vaccines” were introduced under Operation Warp Speed. Transmission electron microscopy of exosomes also demonstrated spike protein Ags on their surface. This cutting-edge research has caused a furor in the scientific community. To determine the mechanism, we analyzed the kinetics of induction of circulating exos … ... Answer– Well, for starters, there’s a research paper that appeared recently in the prestigious Circulation magazine that draws the … The level of spike protein generated through COVID-19 vaccination is much lower than the levels associated … Skip slideshow. Reviewed by Emily Henderson, B.Sc. Research ‘Game-changer’: Spike Protein Increases Heart Attacks & Destroys Immune System. The researchers estimated that the spike protein IgG titers found in saliva are ~10,000-fold lower than that in serum, while SIgA titers are ~1000-fold lower. Most of the ongoing projects aimed at the development of specific therapies and vaccines against COVID-19 use the SARS-CoV-2 spike (S) protein as the main target. SARS-CoV-2 Spike Protein Impairs Endothelial Function via Downregulation of ACE 2. Functional domains of the spike (S) protein are marked and include the N-terminal domain, the receptor binding domain, the fusion domain (Fusion), heptad repeats 1 and 2 (HR1 and HR2) (20, 42), the transmembrane (TM) domain, and the cytoplasmic (Endo) domain (43). “Spike protein is a deadly protein,” Dr. Peter McCullough, a trained internist, cardiologist and epidemiologist, says in a video. Facebook. According to the Doctor, who cites a brand new, peer-reviewed research study out of Japan "They made a mistake - they thought the spike protein was a great target antigen, only… Because the RBD is the part of the spike that attaches directly to human cells and enables the virus to infect them, it was rightly assumed to be a primary target of the immune system. Scale bar=20 μm. The paper, published in the journal Circulation Research, showed conclusively that Covid-19 is a vascular disease, demonstrating exactly how the SARS … One of these ‘is that the spike protein, on its own, is almost entirely responsible for the damage to the cardiovascular system, if it gets into circulation. Thickened alveolar septa (red arrowhead) and mononuclear cell (red arrow). A, Representative H&E histopathology of lung specimens from 8- to 12 wk-old male Syrian hamsters 5-day post administration of pseudovirus overexpressing Spike protein (Pseu-Spike) or mock virus in control group (n=3 mice per group, 1×10 8 PFU). 30-04-2021. They showed that the spike protein damaged the cells by binding ACE2. New mouse model makes it easier and safer to study COVID-19 lung injury.. Now, a major new study shows that they also play a key role in the disease itself. Scientists have known for a while that SARS-CoV-2’s distinctive “spike” proteins help the virus infect its host by latching on to healthy cells. The novel coronavirus’ spike protein plays additional key role in illness. The paper, published on April 30, 2021, in Circulation Research, also shows conclusively that COVID-19 is a vascular disease, demonstrating exactly how the SARS-CoV-2 virus damages and attacks the vascular system on a cellular level. UND DIE IMPFUNG ENTHÄLT GENAU DIESES SPIKE PROTEIN! SARS-CoV-2 Spike Protein Impairs Endothelial Function via Downregulation of ACE 2 (Circulation Research) The novel coronavirus’ spike protein plays additional key role in illness - Salk Institute for Biological Studies (Salk Institute) SARS-CoV-2 spike protein impairment of endothelial function does not impact vaccine safety (Salk Institute) 1–4 ACE2 has distinct roles ranging from catalytic activities with various substrates, as functional … The level of spike protein generated through COVID-19 vaccination is much lower than the levels associated … It does not get cleaved to make S1 protein, because that cleavage site has been mutated to keep that from happening, but it does bind to human ACE2 receptors just like the wild-type protein. Skip slideshow. After attaching itself to the ACE2 protein on healthy cells, the spike disrupts signaling from ACE2 to the mitochondria - the cell's energy-generating structures - causing the mitochondria to become damaged, researchers reported on Friday in Circulation Research. Angiotensin-converting enzyme 2 (ACE2) is an enzyme that can be found either attached to the membrane of cells (mACE2) in the intestines, kidney, testis, gallbladder, and heart or in a soluble form (sACE2). “Spike protein is a deadly protein,” Dr. Peter McCullough, an internist, cardiologist and trained epidemiologist, says in a video. The Salk Institute article refers to this science paper published in Circulation Research: SARS-CoV-2 Spike Protein Impairs Endothelial Function via Downregulation of ACE 2. In addition, this protein is highly glycosylated as it contains 21 to 35 N-glycosylation sites. Thickened alveolar septa (red arrowhead) and mononuclear cell (red arrow). Scientists have known for a while that SARS-CoV-2's distinctive "spike" proteins help the virus infect its host by latching on to healthy cells. In the case of natural infection, circulation of the S protein in a soluble form is unlikely. The paper, published in the journal Circulation Research, showed conclusively that Covid-19. 189. 6 It can cause inflammation and clotting in any tissue in which it accumulates. Scientists have known for a while that SARS-CoV-2 ’s distinctive “spike” proteins help the virus … New research by Yuyang Lei and colleagues published in the journal Circulation Research sheds new light on how the spike protein might play a critical role in the widespread damage caused by SARS-CoV2, and offers insight into treating the complications of COVID-19. Yuyang Lei, Jiao Zhang, Cara R. Schiavon, Ming He, Lili Chen, Hui Shen, Yichi Zhang, There is evidence indicating that spike protein during infection can lead to damage, but this isn’t representative of the situation in vaccination. The study was published on March 31, 2021, in the journal Circulation Research, showing how the spike protein damages cells – confirming that COVID-19 is primarily a vascular disease. ... there’s a research paper that appeared recently in the prestigious Circulation magazine that draws the same conclusion. There is evidence indicating that spike protein during infection can lead to damage, but this isn’t representative of the situation in vaccination. New research by Yuyang Lei and colleagues published in the journal Circulation Research sheds new light on how the spike protein might play a critical role in the widespread damage caused by SARS-CoV2, and offers insight into treating the complications of COVID-19. Using a newly developed mouse model of acute lung injury, researchers found that exposure to the SARS-CoV-2 spike protein alone was enough to induce COVID-19-like symptoms including severe inflammation of the lungs.. SARS-CoV-2, the virus that causes COVID-19, is covered in … Research cited below has documented that the viral spike protein is able to initiate a cascade of events that triggers damage to distant organs in COVID-19 patients. This study defined sex differences in tissue ACE2 expression and their impact on SARS-CoV-2 S protein regulation of ACE2 activity and AngII levels.

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